Evaluation of some blood parameters in the experimental autoimmune encephalomyelitis mouse model

Multiple sclerosis (MS) is a chronic neuroinflammatory demyelinating disorder of the central nervous system with unclear exact etiology. The experimental autoimmune encephalomyelitis (EAE) model in C57BL/6 mice most common animal for MS sharing many clinical and pathophysiological features to expand our knowledge on pathophysiology disease develop novel treatment strategies. current study was planned evaluate effect EAE hematologic plasma total protein albumin levels mice.
 induced myelin oligodendrocyte glycoprotein (MOG35-55) peptide female mice. clinically caused paralyzed tail, hind limb paresis, uncoordinated movement EAE-induced hematologically had mild increase white blood cell count without altering neutrophil-lymphocyte ratio but no change vital hematological parameters such as red count, packed volume, hemoglobin level. Moreover, produced rise level an attenuation In conclusion, findings show that might not cause any significant hematologically, except slight produce changes parameter effects, study, could take consideration terms understanding developing therapeutic approach disease.